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I started out on Differin, Duac and an oral skin antibiotic, which improved my acne about 90%. About 2 weeks ago, my dermatologist took me off the oral antibiotic and switched me over to just Atralin. So far, I am breaking out again but I am hoping it is just the initial adjustment period causing it to do this (getting better before it gets worse). I will give it another week or two and then I will probably go back in if it doesn't improve. The upside is that it does not cause a lot of peeling or irritation, as did the other creams. I have very sensitive and maturing skin so I thought this would be a great choice for me.