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Insulin therapy is effective in achieving the appropriate levels of glycemia, but it is inconvenient and expensive.

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In vitro, the protein binding exhibited by glyburide is predominantly non-ionic, whereas that of other sulfonylureas (chlorpropamide, tolbutamide, tolazamide) is predominantly ionic.

Severe allergic reactions (rash; hives; itching; difficulty breathing, joint or muscle pain, tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); blisters on the skin; confusion; fainting; fever, chills, or persistent sore throat; irregular heartbeat; low blood sugar symptoms (eg, anxiety, dizziness, drowsiness, fast heartbeat, headache, lightheadedness, tremors, unusual sweating, weakness); severe or persistent blurred vision or other vision problems; symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, stomach pain, yellowing of the eyes or skin); unusual bruising or bleeding; unusual tiredness or weakness.

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Changes in the lipid profile associated with glyburide and metformin hydrochloride treatment were similar to those seen with glyburide, metformin, and placebo.

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Intravenous single-dose studies in normal subjects demonstrate that metformin is excreted unchanged in the urine and does not undergo hepatic metabolism (no metabolites have been identified in humans) nor biliary excretion.

Treatment for gestational diabetes aims to keep blood glucose levels equal to those of pregnant women who don't have gestational diabetes.

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When blood sugar cannot be lowered enough by glyburide and metformin hydrochloride your doctor may prescribe injectable insulin or take other measures to control your diabetes.

Know the signs and symptoms of low blood sugar (hypoglycemia), which include headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea.

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Safety Considerations with Pharmacological Treatment of Gestational Diabetes Mellitus.

We conclude that glyburide is an effective alternative to insulin in women with gestational diabetes.

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Symptoms of low blood sugar must be treated before they lead to unconsciousness (passing out).

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